the cause of skin sensitivity is not the contact and action of specific substances, but rather the established state of the skin’s own structure and sensory nerves. The causes include the following possible factors: No. 1 Barrier Function: Skin barrier can effectively prevent the invasion of external harmful factors and the loss of nutrients in the body, the skin barrier function is impaired, is an important reason for skin sensitivity. No. 2 nerve factor: The epidermis also has the sense function, the reason why the epidermal cells produce the sense signal: first, there are two kinds of sensory afferent nerve fibers in the stratum corneum of the skin, the sensory nerve fibers can sense all kinds of outside stimulation factors, the second is that the Keratinocyte surface expresses receptors such as TRP that sense temperature, pain, etc. . Inflammatory Reaction No. 3: It is more difficult to resist the attack of external irritants and allergens than normal skin due to the characteristics of barrier function damage or abnormal nerve function in sensitive skin, easy to occur a series of stimulation or allergic skin inflammation, and then further damage to the skin barrier structure and nerve endings, leading to a vicious cycle. Inflammation is an important factor in sensitive skin.
Serial number
Test Item
Detection model
Detection Index
Anti-inflammatory soothing
Expression of inflammatory factors
(IL-1α)
(IL-8)
Calcium influx
Mast cells
Degranulation
Macrophage
Combined with MTT Cytotoxic morphological observation, the safe concentration of the sample is less than 0.25%